Article
Bypass of Mutagenic O(6)-Carboxymethylguanine DNA Adducts by Human Y- and B-Family Polymerases.
Chemical research in toxicology - 19 Sept 2016
Räz Michael H, Dexter Hannah R, Millington Christopher L, van Loon Barbara, Williams David M, Sturla Shana J
Abstract excerpt
The generation of chemical alkylating agents from nitrosation of glycine and bile acid conjugates in the gastrointestinal tract is hypothesized to initiate carcinogenesis. O(6)-carboxymethylguanine (O(6)-CMG) is a product of DNA alkylation derived from nitrosated glycine. Although the tendency of the structurally related adduct O(6)-methylguanine to code for the misincoporation of TTP during DNA replication is...
Topics
- DNA Adducts
- DNA-Directed DNA Polymerase
- Guanine
- Humans
- Mutagens
- Mutation
- Nitrosation
- Proto-Oncogene Proteins p21(ras)