Article

Model colibactins exhibit human cell genotoxicity in the absence of host bacteria

2018-09-29

Abstract excerpt

Colibactins are genotoxic secondary metabolites produced in select Enterobacteriaceae, which induce downstream DNA double-strand breaks (DSBs) in human cell lines and are thought to promote the formation of colorectal tumors. Although key structural and functional features of colibactins have been elucidated, the full molecular mechanisms regulating these phenotypes remain unknown. Here, we demonstrate that free m...

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Literature Corpus work: 3152273e-ba91-594f-bd97-bfee5c1b5959
DOI: 10.1101/431098

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