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Article

Replication-independent repair of DNA interstrand crosslinks.

Molecular cell - 13 Jul 2012

Williams Hannah L, Gottesman Max E, Gautier Jean

Abstract excerpt

DNA interstrand crosslinks (ICLs) are cytotoxic lesions that covalently link opposite strands of the DNA helix and block DNA unwinding. ICLs are repaired during and outside S phase, and replication-independent ICL repair (RIR) is critical to maintain genomic integrity and to allow transcription in nondividing or slowly dividing cells. Here, we show that the Y family DNA polymerase kappa (Pol κ) is essential for...

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Identifiers

PMID: 22658724
DOI: 10.1016/j.molcel.2012.05.001
PMCID: PMC3666337

Genes

PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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