Article

Geometrically encoded positioning of introns, intergenic segments, and exons in the human genome

2025-05-29

Abstract excerpt

Human tissues require a mechanism to generate durable, yet modifiable, transcriptional memories to sustain cell function across a lifetime. Previously, we demonstrated that nanoscale packing domains couple heterochromatin (cores) and euchromatin (outer zone) into unified reaction volumes that can generate transcriptional memory. In prior work, this framework demonstrated that RNA synthesis occurred within the idea...

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Literature Corpus work: 75e0b13b-3159-5cea-8771-b1ad06488f93
DOI: 10.1101/2025.05.29.656862

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