Article

Ultrafine mapping of chromosome conformation at hundred basepair resolution reveals regulatory genome architecture

2019-08-22

Abstract excerpt

The resolution limit of chromatin conformation capture methodologies (3Cs) has restrained their application in detection of fine-level chromatin structure mediated by cis-regulatory elements (CREs). Here we report two 3C-derived methods, Tri-4C and Tri-HiC, which utilize mult-restriction enzyme digestions for ultrafine mapping of targeted and genome-wide chromatin interaction, respectively, at up to one hundred ba...

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Literature Corpus work: 97c315c8-7fd0-5751-a8d0-aa0aa47b238d
DOI: 10.1101/743005

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