Conserved and species-specific transcription factor co-binding patterns drive divergent gene regulation in human and mouse.

Abstract excerpt

The mouse is widely used as system to study human genetic mechanisms. However, extensive rewiring of transcriptional regulatory networks often confounds translation of findings between human and mouse. Site-specific gain and loss of individual transcription factor binding sites (TFBS) has caused functional divergence of orthologous regulatory loci, and so we must look beyond this positional conservation to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Binding Sites
• Share to Chromatin
• Share to Conserved Sequence