Article
Principles of regulatory information conservation between mouse and human.
Nature - 20 Nov 2014
Cheng Yong, Ma Zhihai, Kim Bong-Hyun, Wu Weisheng, Cayting Philip, Boyle Alan P, Sundaram Vasavi, Xing Xiaoyun, Dogan Nergiz, Li Jingjing, Euskirchen Ghia, Lin Shin, Lin Yiing, Visel Axel, Kawli Trupti, Yang Xinqiong, Patacsil Dorrelyn, Keller Cheryl A, Giardine Belinda, Kundaje Anshul, Wang Ting, Pennacchio Len A, Weng Zhiping, Hardison Ross C, Snyder Michael P
Abstract excerpt
To broaden our understanding of the evolution of gene regulation mechanisms, we generated occupancy profiles for 34 orthologous transcription factors (TFs) in human-mouse erythroid progenitor, lymphoblast and embryonic stem-cell lines. By combining the genome-wide transcription factor occupancy repertoires, associated epigenetic signals, and co-association patterns, here we deduce several evolutionary principles...
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