Article

Disruption of Epithelial Integrity Drives Mesendoderm Differentiation in Human Induced Pluripotent Stem Cells by Enabling BMP and ACTIVIN Sensing

2021-10-23

Abstract excerpt

<h4>ABSTRACT</h4> The processes of primitive streak formation and fate specification in the mammalian epiblast rely on complex interactions between morphogens and tissue organization. Little is known about how these instructive cues functionally interact to regulate gastrulation. We interrogated the interplay between tissue organization and morphogens by using human induced pluripotent stem cells (hiPSCs) down-re...

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Literature Corpus work: bd2768e3-e523-59b5-ab64-e4fea7e6b92d
DOI: 10.1101/2021.10.22.465459

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