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Article

Self-organization of a functional human organizer by combined WNT and NODAL signalling

2017-12-15

Abstract excerpt

In amniotes, the development of the primitive streak (PS) and its accompanying “organizer” define the first stages of gastrulation. Despite detailed characterization in model organisms, the analogous human structures remain a mystery. We have previously shown that when stimulated with BMP4, micropatterned colonies of human embryonic stem cells (hESCs) self-organize to generate early embryonic germ layers 1 . Here...

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Literature Corpus work
39611c67-84fc-5680-bdd7-b6bfb319fe5c
DOI
10.1101/234633
Open publication

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Self-organization of a functional human organizer by combined WNT and NODAL signallingDOI 10.1101/234633
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