Article
Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures.
Nature cell biology - 1 Aug 2018
Sozen Berna, Amadei Gianluca, Cox Andy, Wang Ran, Na Ellen, Czukiewska Sylwia, Chappell Lia, Voet Thierry, Michel Geert, Jing Naihe, Glover David M, Zernicka-Goetz Magdalena
Abstract excerpt
Embryonic stem cells can be incorporated into the developing embryo and its germ line, but, when cultured alone, their ability to generate embryonic structures is restricted. They can interact with trophoblast stem cells to generate structures that break symmetry and specify mesoderm, but their development is limited as the epithelial-mesenchymal transition of gastrulation cannot occur. Here, we describe a system...
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