Article

TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting multiple endogenous signaling pathways

2021-07-16

Abstract excerpt

<h4>Summary</h4> Genetic differences between pluripotent stem cell lines causes variable activity of extra-cellular signaling pathways, which limits the reproducibility of directed differentiation protocols. Here we used human embryonic stem cells (hESCs) to interrogate how exogenously provided factors modulate endogenous signaling events during specification of foregut endoderm lineages. We find that TGF-β1 acti...

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Literature Corpus work: a7c2978a-3010-5d27-ae14-eb21684fbda4
DOI: 10.1101/2021.07.15.452587

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