Article

Molecularly-guided spatial proteomics captures single-cell identity of the healthy and diseased nervous system

2025-02-11

Abstract excerpt

Single-cell spatial proteomics (scSP) holds substantial potential for profiling healthy and diseased tissues. The emerging method of molecularly-guided unbiased scSP has mostly been applied to peripheral somatic tissues. Here, we optimize and apply scSP to the healthy and diseased mammalian brain, using molecularly-guided laser capture microdissection and unbiased mass spectrometry. We systematically evaluate the...

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Literature Corpus work: a73a4018-a400-5d4b-a5a9-05fb8df09b46
DOI: 10.1101/2025.02.10.637505

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