Article

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease relevant pathologies

2022-01-19

Abstract excerpt

<h4>Manuscript summary</h4> There are hundreds of risk genes associated with autism spectrum disorder (ASD), but signaling networks at the protein level remain unexplored. We use neuron-specific proximity-labeling proteomics (BioID) to identify protein-protein interaction (PPI) networks for 41 ASD-risk genes. Neuron-specific PPI networks, including synaptic transmission proteins, are disrupted by de novo missens...

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Literature Corpus work: a567da41-be99-5c28-860d-3076dde58ccd
DOI: 10.1101/2022.01.17.476220

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