Article

Global ubiquitylation analysis of mitochondria in primary neurons identifies physiological Parkin targets following activation of PINK1

2021-04-01

Abstract excerpt

<h4>SUMMARY</h4> Autosomal recessive mutations in PINK1 and Parkin cause Parkinson’s disease. How activation of PINK1 and Parkin leads to elimination of damaged mitochondria by mitophagy is largely based on cell culture studies with few molecular studies in neurons. Herein we have undertaken a global proteomic-analysis of mitochondria from mouse neurons to identify ubiquitylated substrates of endogenous Parkin ac...

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Literature Corpus work: 36ce53b8-9b36-589d-9392-a767fd90e9f4
DOI: 10.1101/2021.04.01.438131

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