Pre-existing stem cell heterogeneity dictates clonal responses to acquisition of cancer driver mutations

Abstract excerpt

Cancer cells display wide phenotypic variation even across patients with the same mutations. Differences in the cell of origin provide a potential explanation, but these assays have traditionally relied on surface markers, lacking the clonal resolution to distinguish heterogeneous subsets of stem and progenitor cells. To address this challenge, we developed STRACK, an unbiased framework to longitudinally trace clo...

Topics

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• Clonal Evolution
• Cohort Studies
• Genomics
• Heterografts
• High-Throughput Nucleotide Sequencing
• Leukemia, Myeloid, Acute
• Mice, Inbred NOD
• Single-Cell Analysis

Identifiers and source

Literature Corpus work

bd0a1ef5-6c30-5b84-ade8-310c30d193ba

DOI

10.1101/2024.05.14.594084