Article
[Leukemia stem cell and clonal evolution].
Nihon rinsho. Japanese journal of clinical medicine - 1 Jun 2014
Yoshimi Akihide, Kurokawa Mineo
Abstract excerpt
The introduction of next generation sequencing technology has greatly broadened our view on the genetic landscape of hematological malignancies. The first comprehensive experiment of acute myeloid leukemia(AML) using genome-wide analysis has also shed light on the clonal evolution of AML, which seems to have been underestimated. It is now possible to precisely define clonal size and selection at different stages....
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