Article

Real-time observation of light-controlled transcription in living cells

2017-04-28

Abstract excerpt

Gene expression is a tightly controlled process that is coordinated in space and time. To dissect its dynamic regulation with high temporal resolution, we introduce an optogenetic tool termed BLInCR (Blue Light-Induced Chromatin Recruitment) that combines rapid and reversible light-dependent recruitment of effector proteins with a real-time readout for transcription. We used BLInCR to control the activity of a rep...

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Literature Corpus work: bcd9a5cd-9b7b-54f4-bbfe-6f6bc9cd1d8b
DOI: 10.1101/132050

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