Optogenetic Control of the Integrated Stress Response Limits Glioblastoma Invasion

Abstract excerpt

The integrated stress response (ISR) is a highly conserved cellular signaling network, allowing cells to adapt and respond to various stressors. In one of the toughest cancers to date, glioblastoma multiforme (GBM) with aggressive spread and high recurrence rates, the role of the ISR is yet to be well understood - whether activation may suppress or promote this disease – and drug-treatment of GBM has thus far show...

Topics

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• CRISPR and Genetic Engineering
• Extracellular Signal-Regulated MAP Kinases
• Lung Neoplasms
• Molecular Targeted Therapy
• Optogenetics
• Protein Conformation
• Protein Kinase Inhibitors
• Protein Multimerization

Identifiers and source

Literature Corpus work

65c0f370-f91a-55a2-8c57-d0856eca3b2c

DOI

10.1101/2025.08.22.671866