Article

Requirements for mammalian promoters to decode transcription factor dynamics

2021-10-13

Abstract excerpt

In response to different stimuli many transcription factors (TFs) display different activation dynamics that trigger the expression of specific sets of target genes, suggesting that promoters have a way to decode them. Combining optogenetics, deep learning-based image analysis and mathematical modeling, we find that decoding of TF dynamics occurs only when the coupling between TF binding and transcription pre-init...

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Literature Corpus work: 4cee21b2-a7e7-5d44-ae29-e4b962dc6bcf
DOI: 10.1101/2021.10.12.464037

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