Article

Separation-of-function mutants reveal the NF-κB-independent involvement of IκBα in the regulation of stem cell and oncogenic programs

2023-06-22

Abstract excerpt

We previously demonstrated that the NF-κB inhibitor IκBα binds the chromatin together with PRC2 to regulate a subset of developmental- and stem cell-related genes. This alternative function has been elusive in both physiological and disease conditions because of the predominant role of IκBα as a negative regulator of NF-κB. We here uniquely characterize specific residues of IκBα that allow the generation of separa...

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Literature Corpus work: bc82b3cd-39f5-5335-9841-118c8f086aed
DOI: 10.1101/2023.06.21.545928

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Separation-of-function mutants reveal the NF-κB-independent involvement of IκBα in the regulation of stem cell and oncogenic programsDOI 10.1101/2023.06.21.545928Read

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