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Article

Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling.

Nature communications - 29 Sept 2017

Rahnamoun Homa, Lu Hanbin, Duttke Sascha H, Benner Christopher, Glass Christopher K, Lauberth Shannon M

Abstract excerpt

Inflammation influences cancer development, progression, and the efficacy of cancer treatments, yet the mechanisms by which immune signaling drives alterations in the cancer cell transcriptome remain unclear. Using ChIP-seq, RNA-seq, and GRO-seq, here we demonstrate a global overlap in the binding of tumor-promoting p53 mutants and the master proinflammatory regulator NFκB that drives alterations in enhancer and...

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Share to Cell Line, Tumor
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to NF-kappa B

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Share to Tumor Necrosis Factor-alpha

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 28963538
DOI: 10.1038/s41467-017-01117-y
PMCID: PMC5622043

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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