Article

Essential role of single-stranded DNA-binding proteins Ssb1 and Ssb2 in maintaining intestinal epithelial homeostasis

2025-11-14

Abstract excerpt

<title>Abstract</title> <bold>Ssb1 and Ssb2</bold> are single-stranded DNA-binding proteins with overlapping roles in genome stability. Both contain an OB-fold domain and interact with C9orf80 and IntS3, components of the <bold>Integrator complex</bold> which regulates snRNA processing, enhancer RNA biogenesis, and resolution of <bold>promoter-proximal RNA polymerase II (Pol II) pausing or early terminat...

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Literature Corpus work: 07c310bc-fe51-5ccf-878a-b0d4a4294f36
DOI: 10.21203/rs.3.rs-8071769/v1

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