Article

Escape From Oncogene-Induced Senescence is Controlled by POU2F2 and Memorized by Chromatin Scars

2022-07-02

Abstract excerpt

<h4>Summary</h4> Although oncogene-induced senescence (OIS) is a potent tumor-suppressor mechanism, recent studies revealed that cells can escape from OIS with features of transformed cells. However, the mechanisms that promote OIS escape remain unclear, and evidence of post-senescent cells in human cancers is missing. Here, we unravel the regulatory mechanisms underlying OIS escape using dynamic multidimensional...

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Literature Corpus work: 91746e31-345f-57f5-be6f-01117787097b
DOI: 10.1101/2022.06.29.497942

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