Article

Inactivation of HIF-P4H-1 Stabilizes IKKα, Modulates Non-Canonical NF-κB Signaling, and Sensitizes Cancer Cells to Cell Death

2026-07-20

Abstract excerpt

Hypoxia and NF-κB signaling are well-established drivers of cancer progression and treatment failure, yet the oxygen-dependent regulation of non-canonical NF-κB signaling remains poorly defined. Here, we identify hypoxia-inducible factor prolyl-4-hydroxylase-1 (HIF-P4H-1/EGLN2) as a key modulator of the non-canonical NF-κB pathway. Using integrated biochemical, genetic, proteomic, and transcriptomic analyses acros...

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Literature Corpus work: 7f1d5d5a-d4d9-5cbf-85b0-75d1f4f5b662
DOI: 10.64898/2026.07.17.739273

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