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Article

Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity.

Cell stem cell - 7 Jan 2016

Chiacchiera Fulvio, Rossi Alessandra, Jammula SriGanesh, Piunti Andrea, Scelfo Andrea, Ordóñez-Morán Paloma, Huelsken Joerg, Koseki Haruhiko, Pasini Diego

Abstract excerpt

Polycomb repressive complexes (PRCs) are among the most important gatekeepers of establishing and maintaining cell identity in metazoans. PRC1, which plays a dominant role in this context, executes its functions via multiple subcomplexes, which all contribute to H2AK119 mono-ubiquitination (H2Aubq). Despite our comprehensive knowledge of PRC1-dependent H2Aubq in embryonic stem cells and during early development,...

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Identifiers

PMID: 26526724
DOI: 10.1016/j.stem.2015.09.019

Genes

PRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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