Article

Morphological Changes Induced by TKS4 Deficiency Can Be Reversed by EZH2 Inhibition

2024-03-13

Abstract excerpt

<h4>Background: </h4> The scaffold protein tyrosine kinase substrate 4 (TKS4) undergoes tyrosine phos-phorylation by the epidermal growth factor receptor (EGFR) pathway via Src kinase. The TKS4 deficiency in humans is responsible for the manifestation of a genetic disorder known as Frank-Ter Haar syndrome (FTHS). Based on our earlier investigation, the absence of TKS4 triggers migration, invasion, and epithelial-m...

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Literature Corpus work: f0fd567f-5c96-5098-bf93-b420f827b1f0
DOI: 10.20944/preprints202403.0787.v1

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