Article

E2f coordinates the cell cycle and cell fate of hematopoietic progenitors to drive stress myelopoiesis

2025-06-18

Abstract excerpt

<h4>ABSTRACT</h4> During inflammation, cytokines such as Tnfα, Il1β and Il6 stimulate hematopoietic stem and progenitor cells (HSPCs) to proliferate and accelerate the production of inflammatory cells from the myeloid lineage through a process called stress myelopoiesis. Genetic inactivation of repressors of cell cycle activity in HSPCs is sufficient to recapitulate stress myelopoiesis, suggesting that the cell c...

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Literature Corpus work: 79c98085-1fd5-5e2a-b824-53bcb0f7dc46
DOI: 10.1101/2025.06.16.659412

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