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Mammalian cells contain two functionally distinct PBAF complexes incorporating different isoforms of PHF10 signature subunit

24 Apr 2014

Abstract excerpt

The PBAF subtype of the mammalian chromatin remodeling SWI/SNF complex has wide and diverse functions in transcription regulation and development, being both transcription activator and repressor. However, a mechanism accounting for such functional diversity remains unclear. Human PHF10/BAF45a subunit of the PBAF complex plays an important role in brain development but has not been studied sufficiently. We have...

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PMID: 24763304
DOI: 10.4161/cc.28922

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