Article
IκBα deficiency imposes a fetal phenotype to intestinal stem cells.
EMBO reports - 4 Jun 2020
Marruecos Laura, Bertran Joan, Guillén Yolanda, González Jéssica, Batlle Raquel, López-Arribillaga Erika, Garrido Marta, Ruiz-Herguido Cristina, Lisiero Dominique, González-Farré Mónica, Arce-Gallego Sara, Iglesias Mar, Nebreda Angel R, Miyamoto Shigeki, Bigas Anna, Espinosa Lluís
Abstract excerpt
The intestinal epithelium is a paradigm of adult tissue in constant regeneration that is supported by intestinal stem cells (ISCs). The mechanisms regulating ISC homeostasis after injury are poorly understood. We previously demonstrated that IκBα, the main regulator of NF-κB, exerts alternative nuclear functions as cytokine sensor in a subset of PRC2-regulated genes. Here, we show that nuclear IκBα is present in...
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