Article

Cell Type-Specific Effects of miR-21 Loss Attenuate Tumor Progression in MYC-Driven Prostate Cancer

2025-05-18

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant microRNA expression is common in cancer, yet cell-type-specific microRNA activity in the tumor microenvironment (TME) remains poorly understood. Here, we show that germline deletion of miR-21 significantly attenuated the progression of MYC-driven prostate cancer (PCa), reducing prostate weight, tumor burden, and proliferation index in Hi-Myc mice. In situ hybridization revealed elevated...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bc4fb965-f602-544b-bfd8-f3bf8a569c2f
DOI: 10.1101/2025.05.14.654101

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell Type-Specific Effects of miR-21 Loss Attenuate Tumor Progression in MYC-Driven Prostate CancerDOI 10.1101/2025.05.14.654101Read

Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancerSemantic proximity Read

Convergent alterations in the tumor microenvironment of MYC-driven human and murine prostate cancerSemantic proximity Read

IL-1β/IL-6 signaling circuit in the tumor microenvironment drives prostate cancer developmentSemantic proximity Read

MiR-21 is required for anti-tumor immune response in mice: an implication for its bi-directional roles.Semantic proximity Read

Macrophage proliferation machinery leads to PDAC progression, but susceptibility to innate immunotherapySemantic proximity Read

MicroRNA-27a-5p regulation by promoter methylation and MYC signaling in prostate carcinogenesis.Semantic proximity Read

Cell-type specific expression of oncogenic and tumor suppressive microRNAs in the human prostate and prostate cancerSemantic proximity Read

Inhibition of miR-21 Regulates Mutant KRAS Effector Pathways and Intercepts Pancreatic Ductal Adenocarcinoma Development.Semantic proximity Read

JUN mediates senescence and immune cell recruitment to prevent prostate cancer progressionSemantic proximity Read

Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFosSemantic proximity Read

PMEPA1 promotes androgen receptor‐negative prostate cell proliferation through suppressing the Smad3/4–c‐Myc–p21$^{{\rm Cip1}}$ signaling pathwaySemantic proximity Read

Testicular sex cord–stromal tumors in mice with constitutive activation of PI3K and loss of PtenSemantic proximity Read