Article

Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFos

2024-06-09

Abstract excerpt

Prostate cancer (PC) is the most common male visceral cancer, and second leading cause of cancer mortality in men in the Western world. Using a forward-mutagenesis Sleeping Beauty (SB) transposon-based screen in a Probasin Cre-Recombinase ( Pb-Cre ) Pten -deficient mouse model of PC, we identified Arid1a loss as a driver in the development of metastatic disease. The insertion of transposon in the Arid1a gene r...

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Literature Corpus work: 9522b961-ccb3-577d-a233-f098df71ec15
DOI: 10.1101/2024.06.07.597912

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Loss of ARID1A accelerates prostate tumourigenesis with a proliferative collagen-poor phenotype through co-operation with AP1 subunit cFosDOI 10.1101/2024.06.07.597912Read

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