Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MicroRNA-27a-5p regulation by promoter methylation and MYC signaling in prostate carcinogenesis.

Cell death & disease - 7 Feb 2018

Barros-Silva Daniela, Costa-Pinheiro Pedro, Duarte Henrique, Sousa Elsa Joana, Evangelista Adriane Feijó, Graça Inês, Carneiro Isa, Martins Ana Teresa, Oliveira Jorge, Carvalho André L, Marques Márcia M, Henrique Rui, Jerónimo Carmen

Abstract excerpt

Upregulation of MYC and miRNAs deregulation are common in prostate cancer (PCa). Overactive MYC may cause miRNAs' expression deregulation through transcriptional and post-transcriptional mechanisms and epigenetic alterations are also involved in miRNAs dysregulation. Herein, we aimed to elucidate the role of regulatory network between MYC and miRNAs in prostate carcinogenesis. MYC expression was found upregulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azacitidine
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Gene Regulatory Networks

Share to Prostatic Neoplasms

Share to Prostatic Neoplasms, Castration-Resistant

Share to Proto-Oncogene Proteins c-myc

Share to Response Elements

Source

Open in PubMed Open full text

Identifiers

PMID: 29415999
DOI: 10.1038/s41419-017-0241-y
PMCID: PMC5833437

Genes

MYC
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-27a-5p regulation by promoter methylation and MYC signaling in prostate carcinogenesis.PMID 29415999Read ↗

miR-377 inhibits the tumorous behavior of prostate cancer cells by targeting MYCSemantic proximity Read ↗

c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene NetworksSemantic proximity Read ↗

PDLIM4 repression by hypermethylation as a potential biomarker for prostate cancer.Semantic proximity Read ↗

miR-377 regulates the tumorous behaviors of prostate cancer cells by targeting of MYC mRNA via its interaction with BCL-2/Bax, PTEN, and CDK4Semantic proximity Read ↗

Cell Type-Specific Effects of miR-21 Loss Attenuate Tumor Progression in MYC-Driven Prostate CancerSemantic proximity Read ↗

A multiplatform approach identifies miR-152-3p as a common epigenetically regulated onco-suppressor in prostate cancer targeting TMEM97Semantic proximity Read ↗

Elevated expression of prostate cancer-associated genes is linked to down-regulation of microRNAsSemantic proximity Read ↗

Histone Demethylase KDM5C Drives Prostate Cancer Progression by Promoting EMTSemantic proximity Read ↗

MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activitySemantic proximity Read ↗

MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activitySemantic proximity Read ↗

CUL4B/miR‐33b/C‐MYC axis promotes prostate cancer progressionSemantic proximity Read ↗

Hsa-miR-1-2/miR-133a-1 Cluster Expression Silencing by DNA Hypermethylation Triggers Oncogenes Contributing to Prostate Cancer AggressivenessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.