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Article

Inhibition of miR-21 Regulates Mutant KRAS Effector Pathways and Intercepts Pancreatic Ductal Adenocarcinoma Development.

Cancer prevention research (Philadelphia, Pa.) - 1 Jul 2020

Chu Nina J, Anders Robert A, Fertig Elana J, Cao Minwei, Hopkins Alexander C, Keenan Bridget P, Popovic Aleksandra, Armstrong Todd D, Jaffee Elizabeth M, Zimmerman Jacquelyn W

Abstract excerpt

Almost all pancreatic ductal adenocarcinomas (PDA) develop following KRAS activation, which triggers epithelial transformation and recruitment of desmoplastic stroma through additional transcriptional and epigenetic regulation, but only a few of these regulatory mechanisms have been described. We profiled dysregulated miRNAs starting with the earliest premalignant pancreatic intraepithelial neoplasias (PanIN) in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Share to Proto-Oncogene Proteins p21(ras)

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Identifiers

PMID: 32409593
DOI: 10.1158/1940-6207.CAPR-20-0053
PMCID: PMC7372516

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