Article

Testicular sex cord–stromal tumors in mice with constitutive activation of PI3K and loss of Pten

2024-09-19

Abstract excerpt

Testicular tumors are the most common malignancy of young men and tumors affecting the testis are caused by somatic mutations in germ or germ-like cells. The PI3K pathway is constitutively activated in about one third of testicular cancers. To investigate the role of the PI3K pathway in transforming stem-like cells in the testis, we investigated tumors derived from mice with post-natal, constitutive activation of...

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Literature Corpus work: f2d22dcf-49a1-5bd3-8164-0506d05ad7ab
DOI: 10.1101/2024.09.16.613175

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