Macrophage proliferation machinery leads to PDAC progression, but susceptibility to innate immunotherapy

Abstract excerpt

Tumor-associated macrophages (TAMs) are involved in many aspects of cancer progression and correlate with poor clinical outcomes in many cancer types, including pancreatic ductal adenocarcinomas (PDACs). Previous studies have shown that TAMs can populate PDAC tumors not only by monocyte recruitment but also by local proliferation. However, the impact local proliferation might have on macrophage phenotype and cance...

Topics

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• Carcinogenesis
• Carcinoma, Pancreatic Ductal
• Mice, Inbred NOD
• Mice, SCID
• Pancreas
• Pancreatic and Hepatic Oncology Research
• Pancreatic Neoplasms
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

2ee0ca0a-9ea5-5f42-8d59-d3a1aa63f38c

DOI

10.1101/2021.11.08.467770