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Astrocytic RNA editing regulates the host immune response to alpha-synuclein

2024-02-28

Abstract excerpt

RNA editing is a post transcriptional mechanism that targets changes in RNA transcripts to modulate innate immune responses. We report the role of astrocyte specific, ADAR1 mediated RNA editing in neuroinflammation in Parkinson’s disease. We generated hiPSC-derived astrocytes, neurons and co-cultures and exposed them to small soluble alpha-synuclein aggregates. Oligomeric alpha-synuclein triggered an inflammatory...

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Identifiers and source

Literature Corpus work
bc35a5f1-581f-55e8-8cba-4ae83b75cc60
DOI
10.1101/2024.02.26.582055
Open publication

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Astrocytic RNA editing regulates the host immune response to alpha-synucleinDOI 10.1101/2024.02.26.582055
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