Article

Immunosuppressive tocilizumab prevents astrocyte induced neurotoxicity in hiPSC-LRRK2 Parkinson’s disease by targeting receptor interleukin-6

2022-08-25

Abstract excerpt

Parkinson’s disease (PD) is associated with premature death of dopamine-producing neurons in the brain. Previous studies have shown that astrocytes of PD patients may contribute to neuronal degeneration by mechanisms involving both direct cell-to-cell contact and transfer of soluble molecules. Since it has been proposed that PD patients exhibit an overall pro-inflammatory state, and since astrocytes are key mediat...

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Literature Corpus work: f4b94fcb-890c-5bcd-b9c3-6c645730ea7a
DOI: 10.1101/2022.08.23.504918

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