Article
RNA Editing in Neurological and Neurodegenerative Disorders.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Costa Cruz Pedro Henrique, Kawahara Yukio
Abstract excerpt
The brain is one of the organs that are preferentially targeted by adenosine-to-inosine (A-to-I) RNA editing, a posttranscriptional modification. This chemical modification affects neuronal development and functions at multiple levels, leading to normal brain homeostasis by increasing the complexity of the transcriptome. This includes modulation of the properties of ion channel and neurotransmitter receptors by...
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