Article

Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling

2023-07-24

Abstract excerpt

Astrocyte activation is a common feature of neurodegenerative diseases. However, the ways in which dying neurons influence the activity of astrocytes is poorly understood. RIPK3 signaling has recently been described as a key regulator of neuroinflammation, but whether this kinase mediates astrocytic responsiveness to neuronal death has not yet been studied. Here, we used the MPTP model of Parkinson’s disease to sh...

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Literature Corpus work: b14d2613-daa5-54ec-b55d-4da41d3afa02
DOI: 10.1101/2023.07.21.550097

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