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Article

ADAR1 suppression causes interferon signaling and transposable element transcript accumulation in human astrocytes

25 Oct 2023

Abstract excerpt

Neuroinflammation is a central mechanism of brain aging and Alzheimer’s disease (AD), but the exact causes of age- and AD-related neuroinflammation are incompletely understood. One potential modulator of neuroinflammation is the enzyme adenosine deaminase acting on RNA 1 (ADAR1), which regulates the accumulation of endogenous double-stranded RNA (dsRNA), a pro-inflammatory/innate immune activator. However, the...

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PMID: 38035265
DOI: 10.3389/fnmol.2023.1263369

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