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Article

ADAR Dysfunction in Brain Aging and Alzheimer's Disease

2022-05-01

Abstract excerpt

Neuroinflammation is a central mechanism of brain aging and neurodegenerative disease, but why neuroinflammation develops with aging is incompletely understood. Adenosine deaminase RNA specific (ADAR) proteins are potential suppressors of neuroinflammation through their adenosine‐to‐inosine (A‐to‐I) editing and subsequent inhibition of double‐stranded RNA (dsRNA, an innate immune activator). However, the role of A...

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Literature Corpus work
0f48b0c5-408b-5c48-a06e-ce419b2d5453
DOI
10.1096/fasebj.2022.36.s1.r3769
Open publication

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ADAR Dysfunction in Brain Aging and Alzheimer's DiseaseDOI 10.1096/fasebj.2022.36.s1.r3769
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