Article

Recapitulation of patient-specific 3D chromatin conformation using machine learning and validation of identified enhancer-gene targets

2021-11-19

Abstract excerpt

Regulatory networks containing enhancer to gene edges define cellular state and their rewiring is a hallmark of cancer. While efforts, such as ENCODE, have revealed these networks for reference tissues and cell-lines by integrating multi-omics data, the same methods cannot be applied for large patient cohorts due to the constraints on generating ChIP-seq and three-dimensional data from limited material in patient...

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Literature Corpus work: 4bbe11ce-dbcd-5ffe-9c90-18d97156eb56
DOI: 10.1101/2021.11.16.468857

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