Article

PON1 Deficiency Promotes TREM2 Pathway-Mediated Microglial Phagocytosis and Inhibits Pro-Inflammatory Cytokines Release in Vitro and in Vivo

2021-08-23

Abstract excerpt

<title>Abstract</title> Paraoxonase 1 (PON1) plays an anti-inflammatory role in the cardiovascular system. Levels of serum PON1 and polymorphisms in this gene were linked to Alzheimer disease (AD) and Parkinson disease (PD), but its function in the neuroimmune system and AD are not clear. To address this issue, we used PON1 knockout rats previously generated by our lab to investigate the role of PON1 in microg...

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Literature Corpus work: bbf10201-3d3b-57dc-9ff0-25de8fc75763
DOI: 10.21203/rs.3.rs-673247/v2

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