Article

Continuous injection of high-dose lipopolysaccharide modulates microglia polarization via TREM2 to alter the status of septic mice

2022-09-16

Abstract excerpt

<h4>Background: </h4> Neuroinflammation of the central nervous system (CNS) is a prevalent syndrome of brain dysfunction secondary to severe sepsis and is regulated by microglia. Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is known to have protective functions, which modulates microglia polarization to M2 type to reduce inflammatory responses and thereby improve cognition. Methods We examined the eff...

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Literature Corpus work: 8f818882-114a-50a8-9d34-e077b5c86817
DOI: 10.21203/rs.3.rs-2064325/v1

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