Article
Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.
Neurobiology of aging - 1 Jun 2016
Zheng Honghua, Liu Chia-Chen, Atagi Yuka, Chen Xiao-Fen, Jia Lin, Yang Longyu, He Wencan, Zhang Xilin, Kang Silvia S, Rosenberry Terrone L, Fryer John D, Zhang Yun-Wu, Xu Huaxi, Bu Guojun
Abstract excerpt
Mutations in triggering receptor expressed on myeloid cells 2 (TREM2), which has been proposed to regulate the inflammatory responses and the clearance of apoptotic neurons and/or amyloid-β, are genetically linked to increased risk for late-onset Alzheimer's disease (AD). Interestingly, a missense variant in TREM-like transcript 2 (TREML2), a structurally similar protein encoded by the same gene cluster with...
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