Article

PON1 deficiency promotes TREM2 pathway-mediated microglial phagocytosis and inhibits LPS-induced pro-inflammatory cytokines release

2020-08-24

Abstract excerpt

<title>Abstract</title> Background Paraoxonase 1 (PON1), an HDL-associated enzyme, plays an anti-inflammatory role in the cardiovascular system. Levels of serum PON1 and polymorphisms in this gene were linked to Alzheimer disease (AD) and Parkinson disease (PD), but its function in the neuroimmune system and AD are not clear. Methods PON1 knockout rats previously generated by our lab were used to investigate...

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Literature Corpus work: 06b368c4-47b7-5080-9753-126169dda894
DOI: 10.21203/rs.3.rs-61789/v1

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