Article

TREM2 knockout, but not the R47H Alzheimer’s variant, reduces neural phagocytosis and survival of human iPSC-derived macrophages

2020-03-05

Abstract excerpt

<title>Abstract</title> <p>BACKGROUND: TREM2 is a microglial cell surface receptor, with risk mutations linked to Alzheimer’s disease (AD), including R47H. Binding of ligands to TREM2 triggers Syk-dependent signalling through the DAP12 co-receptor, leading to phagocytosis, survival, and changes to microglial activation state. In biochemical assays, R47H impairs TREM2 binding to phosphatidylserine, a lipid “eat-me...

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Literature Corpus work: 75a0a34a-3328-5d3c-b307-2e3ff639e16b
DOI: 10.21203/rs.3.rs-16214/v1

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