Article

Phagocytosis is differentially regulated by LPS in M1- and M2-like macrophages via PGE <sub>2</sub> formation and EP4 signaling

2024-10-01

Abstract excerpt

Phagocytosis is a key process in human innate immune response. Human macrophages are important phagocytes engulfing and neutralizing pathogens and cell debris. In addition, they modulate the inflammatory process by releasing cytokines and lipid mediators. However, the link between oxylipins and phagocytosis in different macrophage phenotypes remains poorly understood. In order to better understand the link between...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c583f76c-85df-536d-a6ad-14cdbb1e9b6f
DOI: 10.1101/2024.09.29.615656

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Phagocytosis is differentially regulated by LPS in M1- and M2-like macrophages via PGE <sub>2</sub> formation and EP4 signalingDOI 10.1101/2024.09.29.615656Read

Eicosanoid production by macrophages during inflammation depends on the M1/M2 phenotype.Semantic proximity Read

Macrophages in acute and chronic inflammation.Semantic proximity Read

PON1 deficiency promotes TREM2 pathway-mediated microglial phagocytosis and inhibits LPS-induced pro-inflammatory cytokines releaseSemantic proximity Read

Phenotypic activation and pharmacological outcomes of spontaneously differentiated human monocyte-derived macrophages.Semantic proximity Read

The Role of Macrophages in Atherosclerosis: Pathophysiologic Mechanisms and Treatment Considerations.Semantic proximity Read

Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages.Semantic proximity Read

Biologic Mechanisms of Macrophage Phenotypes Responding to Infection and the Novel Therapies to Moderate Inflammation.Semantic proximity Read

Radical-Generating Activity, Phagocytosis, and Mechanical Properties of Four Phenotypes of Human Macrophages.Semantic proximity Read

Proteomic characterization of four subtypes of M2 macrophages derived from human THP-1 cells.Semantic proximity Read

Pharmacological modulation of monocytes and macrophages.Semantic proximity Read

M1 Means Kill; M2 Means HealSemantic proximity Read

PON1 Deficiency Promotes TREM2 Pathway-Mediated Microglial Phagocytosis and Inhibits Pro-Inflammatory Cytokines Release in Vitro and in VivoSemantic proximity Read