Article

SHIP1 regulates TREM2 signalling and macrophage functions in a hiPSC-derived model

2025-07-05

Abstract excerpt

Genetic and functional studies strongly implicate microglia in the pathology of Alzheimers disease (AD). The Triggering Receptor Expressed on Myeloid cells 2 (TREM2) pathway is an important functional regulator of microglia in AD, promoting phagocytosis of apoptotic cells, debris and pathogenic proteins including amyloid beta. Additionally, genome-wide association studies have identified risk bearing polymorphisms...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce24aeb6-7fde-534b-ad08-dbe9d021e23f
DOI: 10.1101/2025.07.02.662745

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SHIP1 regulates TREM2 signalling and macrophage functions in a hiPSC-derived modelDOI 10.1101/2025.07.02.662745Read

TREM2 knockout, but not the R47H Alzheimer’s variant, reduces neural phagocytosis and survival of human iPSC-derived macrophagesSemantic proximity Read

TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.Semantic proximity Read

SHIP1 modulation and proteome characterization of microgliaSemantic proximity Read

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in PhagocytosisSemantic proximity Read

Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia.Semantic proximity Read

The SHIP1-inflammatory-lipid axis in Alzheimer's disease: from genetic risk to spatiotemporal mechanistic insights.Semantic proximity Read

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.Semantic proximity Read

TREM1 facilitates microglial phagocytosis of amyloid beta.Semantic proximity Read

Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.Semantic proximity Read

INPP5D/SHIP1 regulates endo-lysosomal function and cargo-selective phagocytosis in human microgliaSemantic proximity Read

<i>Trem2</i> promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditionsSemantic proximity Read

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s DiseaseSemantic proximity Read