Article

Asthma-associated genetic variants induce IL33 differential expression through a novel regulatory region.

2020-10-09

Abstract excerpt

<title>Abstract</title> <p>Genome-wide association studies (GWAS) have implicated the IL33 locus in asthma, but the underlying mechanisms remain unclear. Here, we identify a 5 kb region within the GWAS-defined segment that acts as a strong regulatory element in vivo and in vitro. Chromatin conformation capture showed that this 5 kb region loops to the IL33 promoter, potentially regulating its expression. We show...

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Literature Corpus work: bba01964-d1f9-5eb2-a81f-8a456a477fe3
DOI: 10.21203/rs.3.rs-84333/v1

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